Plaque-associated lipids dataset

Trinklein, Timothy; Lam, Fan; Sweedler, Jonathan

doi:10.13012/B2IDB-4907703_V1

Illinois Data Bank - Dataset

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Plaque-associated lipids dataset

Cite this dataset:

Trinklein, Timothy; Lam, Fan; Sweedler, Jonathan (2024): Plaque-associated lipids dataset. University of Illinois at Urbana-Champaign. https://doi.org/10.13012/B2IDB-4907703_V1

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Dataset Description	This dataset contains MALDI imaging and fluorescence imaging data of 5xFAD mice and control animals. 1+2) Animal_1_5xFAD_s1 and s2 : A MATLAB file of 50 micron spatial resolution imaging of whole brain slice from a 5xFAD animal. 3) Slide28_Animal1_stitch_channels__Thioflavin S : A PNG file of the corresponding Thioflavin S- stained fluorescence image obtained post-MSI from the same section. 4) Slide28_Animal1_stitch_merged : A PNG file of the corresponding merged imaged including brightfield, Thioflavin S (GFP channel) and Hoechst staining (DAPI channel) used for image registration 5) mz_bins_use_neg.mat : A MATLAB array of the m/z channels all MSI images (whole brain slice, 50 micron spatial resolution) were binned to in order to enable comparison 6) Animal3_S18_HR.mat : A MATLAB array of high-spatial-resolution (5 micron) imaging of a 5xFAD mouse hippocampus and cortex. Due to the large dataset, 22 m/z channels are included. 7) Animal5_S18_HR.mat : A MATLAB array of high-spatial-resolution (5 micron) imaging of a wildtype mouse hippocampus and cortex 8) mz_features_22.mat : A MATLAB array of the 22 m/z channels included in the high spatial resolution imaging data
Subject	Life Sciences
Keywords	amyloid beta; 5xfad, lipids; maldi;
License	CC BY
Funder	U.S. National Institutes of Health (NIH)-Grant:R01AG078797
Funder	U.S. National Institutes of Health (NIH)-Grant:S10OD032242
Funder	U.S. National Institutes of Health (NIH)-Grant:P30DA018310
Corresponding Creator	Jonathan Sweedler
Downloaded	648 times
Related Materials (2) Code Code for processing multimodal MALDI imaging of amyloid beta plaque-associated lipids Preprint Trinklein TJ, Rubakhin SS, Okyem S, Croslow SW, Asadian M, Sabitha KR, et al. Multimodal mass spectrometry imaging for plaque- and region-specific neurolipidomics in an Alzheimer’s disease mouse model. ChemRxiv. 2024; doi:10.26434/chemrxiv-2024-2hbb7

Versions in Illinois Data Bank

Version	DOI	Comment	Publication Date
2	10.13012/B2IDB-4907703_V2	I am adding additional new data as the original work has been revised and expanded, but accompanies the same publication that has been under review.	2025-10-16
1	10.13012/B2IDB-4907703_V1		2024-10-28

Files


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Animal3_S18_HR.mat 33 MB File
Animal5_S17_HR.mat 31 MB File
Animal_1_5xFAD_s1.mat 1.06 GB File
Animal_1_5xFAD_s2.mat 1.06 GB File
Slide28_Animal1_stitch_channels__Thioflavin S.png 779 KB File
Slide28_Animal1_stitch_merged.png 9.75 MB File
mz_bins_use_neg.mat 31.7 KB File
mz_features_22.mat 376 Bytes File

Change Log

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