Illinois Data Bank - Dataset

Plaque-associated lipids dataset
Cite this dataset:
Trinklein, Timothy; Lam, Fan; Sweedler, Jonathan (2024): Plaque-associated lipids dataset. University of Illinois at Urbana-Champaign. https://doi.org/10.13012/B2IDB-4907703_V1
Dataset Description

This dataset contains MALDI imaging and fluorescence imaging data of 5xFAD mice and control animals.

1+2) Animal_1_5xFAD_s1 and s2 : A MATLAB file of 50 micron spatial resolution imaging of whole brain slice from a 5xFAD animal.
3) Slide28_Animal1_stitch_channels__Thioflavin S : A PNG file of the corresponding Thioflavin S- stained fluorescence image obtained post-MSI from the same section.
4) Slide28_Animal1_stitch_merged : A PNG file of the corresponding merged imaged including brightfield, Thioflavin S (GFP channel) and Hoechst staining (DAPI channel) used for image registration
5) mz_bins_use_neg.mat : A MATLAB array of the m/z channels all MSI images (whole brain slice, 50 micron spatial resolution) were binned to in order to enable comparison
6) Animal3_S18_HR.mat : A MATLAB array of high-spatial-resolution (5 micron) imaging of a 5xFAD mouse hippocampus and cortex. Due to the large dataset, 22 m/z channels are included.
7) Animal5_S18_HR.mat : A MATLAB array of high-spatial-resolution (5 micron) imaging of a wildtype mouse hippocampus and cortex
8) mz_features_22.mat : A MATLAB array of the 22 m/z channels included in the high spatial resolution imaging data
Subject Life Sciences
Keywords amyloid beta; 5xfad, lipids; maldi;
License CC BY
Funder U.S. National Institutes of Health (NIH)-Grant:R01AG078797
Funder U.S. National Institutes of Health (NIH)-Grant:S10OD032242
Funder U.S. National Institutes of Health (NIH)-Grant:P30DA018310
Corresponding Creator Jonathan Sweedler
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Version DOI Comment Publication Date
1 10.13012/B2IDB-4907703_V1 2024-10-28

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