Dataset Search

DNN weights used in the evaluation of the ApproxTuner system. Link to paper: https://dl.acm.org/doi/10.1145/3437801.3446108

This dataset contains data derived from large-scale particle velocimetry measurements obtained at the confluence of the Saline Branch and an unnamed tributary in Illinois. The data were collected using two cameras positioned about the confluence, one mounted on a cable and the other mounted on a tripod. A description of the content of the files can be found in Description of Files.rtf.

A set of chemical entity mentions derived from an NERC dataset analyzing 900 synthetic biology articles published by the ACS. This data is associated with the Synthetic Biology Knowledge System repository (https://web.synbioks.org/). The data in this dataset are raw mentions from the NERC data.

Engineering efficient biocatalysts is essential for metabolic engineering to produce valuable bioproducts from renewable resources. However, due to the complexity of cellular metabolic networks, it is challenging to translate success in vitro into high performance in cells. To meet such a challenge, an accurate and efficient quantification method is necessary to screen a large set of mutants from complex cell culture and a careful correlation between the catalysis parameters in vitro and performance in cells is required. In this study, we employed a mass-spectrometry based high-throughput quantitative method to screen new mutants of 2-pyrone synthase (2PS) for triacetic acid lactone (TAL) biosynthesis through directed evolution in E. coli. From the process, we discovered two mutants with the highest improvement (46 fold) in titer and the fastest kcat (44 fold) over the wild type 2PS, respectively, among those reported in the literature. A careful examination of the correlation between intracellular substrate concentration, Michaelis-Menten parameters and TAL titer for these two mutants reveals that a fast reaction rate under limiting intracellular substrate concentrations is important for in-cell biocatalysis. Such properties can be tuned by protein engineering and synthetic biology to adopt these engineered proteins for the maximum activities in different intracellular environments.

This data comprises image files used in the analysis of Analysis of Nematode Ventral Nerve Cords Suggests Multiple Instances of Evolutionary Addition and Loss of Neurons by Han et al. (bioRxiv, 2025: doi: https://doi.org/10.1101/2025.03.20.644414). It is separated into two folders. The first comprise data using DAPI staining to quantify the number of VNC nuclei in diverse nematodes. The second includes dye-filling data of Mononchus aquaticus.

ALMA Band 4 and 7 observations of the dust continuum in the Class 0 protostellar system L1448 IRS3B. We include the selfcal script, imaging scripts, fits files, and the python scripts for the figures in the paper.

Raw measurement data for umbilical remnants (umbilical vein, umbilical arteries and urachus) in support of Equine Veterinary Journal publication "Normal Regression of the Internal Umbilical Remnant Structures in Standardbred Foals."

This page contains the data for the publication "The pioneer transcription factor Zelda controls the exit from regeneration and restoration of patterning in Drosophila" published in the journal Science Advances.

This repository includes HRLDAS Noah-MP model output generated as part of Bieri et al. (2025) - Implementing deep soil and dynamic root uptake in Noah-MP (v4.5): Impact on Amazon dry-season transpiration. These data are distributed in two different formats: Raw model output files and subsetted files that include data for a specific variable. All files are .nc format (NetCDF) and aggregated into .tar files to facilitate download. Given the size of these datasets, Globus transfer is the best way to download them. Raw model output for four model experiments is available: FD (control), GW, SOIL, and ROOT. See the associated publication for information on the different experiments. These data span an approximately 20 year period from 01 Jun 2000 to 31 Dec 2019. The data have a spatial resolution of 4 km and a temporal frequency of 3 hours. These data are for a domain in the southern Amazon basin (see Figure 1 in the associated publication). Data for each experiment is available as a .tar file which includes 3-hourly NetCDF files. All default Noah-MP output variables are included in each file. As a result, the .tar files are quite large and may take many hours or even days to transfer depending on your network speed and local configurations. These files are named 'noahmp_output_2000_2019_EXP.tar', where EXP is the name of the experiment (FD, GW, SOIL, or ROOT). Subsetted model output at a daily temporal resolution for all four model experiments is also available. These .tar files include the following variables: water table depth (ZWT), latent heat flux (LH), sensible heat flux (HFX), soil moisture (SOIL_M), canopy evaporation (ECAN), ground evaporation (EDIR), transpiration (ETRAN), rainfall rate at the surface (QRAIN), and two variables that are specific to the ROOT experiment: ROOTACTIVITY (root activity function) and GWRD (active root water uptake depth). There is one file for each variable within the tarred files. These files are named 'noahmp_output_subset_2000_2019_EXP.tar', where EXP is the name of the experiment (FD, GW, SOIL, or ROOT). Finally, there is a sample dataset with raw 3-hourly output from the ROOT experiment for one day. The purpose of this sample dataset is to allow users to confirm if these data meet their needs before initiating a full transfer via Globus. This file is named 'noahmp_output_sample_ROOT.tar'. The README.txt file provides information on the Noah-MP output variables in these datasets, among other specifications. Information on HRLDAS Noah-MP and names/definitions of model output variables that are useful in working with these data are available here: http://dx.doi.org/10.5065/ew8g-yr95. Note that some output variables may be listed in this document under a different variable name, so searching for the long name (e.g. 'baseflow' instead of 'QRF') is recommended. Information on additional output variables that were added to the model as part of this study is available here: https://github.com/bieri2/bieri-et-al-2025-EGU-GMD/tree/DynaRoot. Model code, configuration files, and forcing data used to carry out the model simulations are linked in the related resources section.

Historical census data collected at Trelease Woods from 1986 to 2004 with information on tree species, diameter at breast height (DBH), and plot location.

List of differentially expressed genes in human endometrial stromal cells with knockdown of Basigin (BSG) gene expression during decidualization. The BSG siRNA or negative scrambled control siRNA were transfected into human endometrial stromal cells (HESCs) following the protocol of siLentFect™ Lipid (Bio-Rad, Hercules, CA. Following complete knock down of BSG in HESCs (72 hours after adding siRNA), HESCs were treated with medium containing estrogen, progesterone and cAMP to induce decidualization. BSG siRNA and negative control scrambled siRNA were added to the cells every four days (day 0, 4) over the course of the decidualization protocol. Total RNA was harvested at day 6 of the decidualization protocol for microarray analysis. Microarray analysis was performed at the University of Illinois at Urbana-Champaign Roy J. Carver Biotechnology Center. Briefly, 0.2 micrograms of total RNA were labeled using the Agilent two color QuickAmp labeling kit (Agilent Technologies, Santa Clara, CA) according to the manufacturer’s protocol. The optional spike-in controls were not used. Samples were hybridized to Human Gene Expression 4x44K v2 Microarray (Agilent Technologies, Santa Clara, CA) in an Agilent Hybridization Cassette according to standard protocols. The arrays were then scanned on an Axon GenePix 4000B scanner and the images were quantified using Axon GenePix 6.1. Microarray data pre-processing and statistical analyses were done in R (v3.6.2) using the limma package (3.42.0 (Ritchie et al., 2015). Median foreground and median background values from the 4 arrays were read into R and any spots that had been manually flagged (-100 values) were given a weight of zero. The background values were ignored because investigations showed that trying to use them to adjust for background fluorescence added more noise to the data; background was low and even for all arrays, therefore no background correction was done. The individual Cy5 and Cy3 fluorescence for each array were normalized together using the quantile method 3 (Yang and Thorne, 2003). Agilent's Human Gene Expression 4x44K v2 Microarray has a total of 45,220 probes: 1224 probes for positive controls, 153 negative control, 823 labeled “ignore” and 43,118 labeled “cDNA”. The pos+neg+ignore probes were used to ascertain the background level of fluorescence (6, on the log2 scale) then discarded. The cDNA probes comprise 34,127 unique 60mer probes, of which 999 probes are spotted 10 times each and the rest one time each. We averaged the replicate probes for those spotted 10 times and then fit a mixed model that had treatment and dye as fixed effects and array pairing as a random effect (Phipson et al., 2016; Smyth et al., 2005). After fitting the model but before False Discovery Rate (FDR) correction (Benjamini and Hochberg, 1995), probes were filtered out by the following criteria: 1) did not have at least 4/8 samples with expression values > 6 (14,105 probes removed), 2) no longer had an assigned Entrez Gene ID in Bioconductor’s HsAgilentDesign026652.db annotation package (v3.2.3; 2,152 probes removed) (Huber et al., 2015), 3) mapped to the same Entrez Gene ID as another probe but had a larger p-value for treatment effect (4,141 probes removed). This left 13,729 probes representing 13,729 unique genes. <b>*Please note: that there is a discrepancy between the file and the readme as this plain text is the actual data file of this dataset.</b>

The oleaginous, carotenogenic yeast Rhodotorula toruloides has been increasingly explored as a platform organism for the production of terpenoids and fatty acid derivatives. Fatty alcohols, a fatty acid derivative widely used in the production of detergents and surfactants, can be produced microbially with the expression of a heterologous fatty acyl-CoA reductase. Due to its high lipid production, R. toruloides has high potential for fatty alcohol production, and in this study several metabolic engineering approaches were investigated to improve the titer of this product. Fatty acyl-CoA reductase from Marinobacter aqueolei was co-expressed with SpCas9 in R. toruloides IFO0880 and a panel of gene overexpressions and Cas9-mediated gene deletions were explored to increase the fatty alcohol production. Two overexpression targets (ACL1 and ACC1, improving cytosolic acetyl-CoA and malonyl-CoA production, respectively) and two deletion targets (the acyltransferases DGA1 and LRO1) resulted in significant (1.8 to 4.4-fold) increases to the fatty alcohol titer in culture tubes. Combinatorial exploration of these modifications in bioreactor fermentation culminated in a 3.7 g/L fatty alcohol titer in the LRO1Δ mutant. As LRO1 deletion was not found to be beneficial for fatty alcohol production in other yeasts, a lipidomic comparison of the DGA1 and LRO1 knockout mutants was performed, finding that DGA1 is the primary acyltransferase responsible for triacylglyceride production in R. toruloides, while LRO1 disruption simultaneously improved fatty alcohol production, increased diacylglyceride and triacylglyceride production, and increased glucose consumption. The fatty alcohol titer of fatty acyl-CoA reductase-expressing R. toruloides was significantly improved through the deletion of LRO1, or the deletion of DGA1 combined with overexpression of ACC1 and ACL1. Disruption of LRO1 surprisingly increased both lipid and fatty alcohol production, creating a possible avenue for future study of the lipid metabolism of this yeast.

To generate the bibliographic and survey data to support a data reuse study conducted by several Library faculty and accepted for publication in the Journal of Academic Librarianship, the project team utilized a series of web-based online scripts that employed several different endpoints from the Scopus API. The related dataset: "Data for: An Examination of Data Reuse Practices within Highly Cited Articles of Faculty at a Research University" contains survey design and results. <br /> 1) <b>getScopus_API_process_dmp_IDB.asp</b>: used the search API query the Scopus database API for papers by UIUC authors published in 2015 -- limited to one of 9 pre-defined Scopus subject areas -- and retrieve metadata results sorted highest to lowest by the number of times the retrieved articles were cited. The URL for the basic searches took the following form: https://api.elsevier.com/content/search/scopus?query=(AFFIL%28(urbana%20OR%20champaign) AND univ*%29) OR (AF-ID(60000745) OR AF-ID(60005290))&apikey=xxxxxx&start=" & nstart & "&count=25&date=2015&view=COMPLETE&sort=citedby-count&subj=PHYS<br /> Here, the variable nstart was incremented by 25 each iteration and 25 records were retrieved in each pass. The subject area was renamed (e.g. from PHYS to COMP for computer science) in each of the 9 runs. This script does not use the Scopus API cursor but downloads 25 records at a time for up to 28 times -- or 675 maximum bibliographic records. The project team felt that looking at the most 675 cited articles from UIUC faculty in each of the 9 subject areas was sufficient to gather a robust, representative sample of articles from 2015. These downloaded records were stored in a temporary table that was renamed for each of the 9 subject areas. <br /> 2) <b>get_citing_from_surveys_IDB.asp</b>: takes a Scopus article ID (eid) from the 49 UIUC author returned surveys and retrieves short citing article references, 200 at a time, into a temporary composite table. These citing records contain only one author, no author affiliations, and no author email addresses. This script uses the Scopus API cursor=* feature and is able to download all the citing references of an article 200 records at a time. <br /> 3) <b>put_in_all_authors_affil_IDB.asp</b>: adds important data to the short citing records. The script adds all co-authors and their affiliations, the corresponding author, and author email addresses. <br /> 4) <b>process_for_final_IDB.asp</b>: creates a relational database table with author, title, and source journal information for each of the citing articles that can be copied as an Excel file for processing by the Qualtrics survey software. This was initially 4,626 citing articles over the 49 UIUC authored articles, but was reduced to 2,041 entries after checking for available email addresses and eliminating duplicates.

Example scripts and configuration files needed to perform select simulations described in the manuscript "Percolation transition prescribes protein size-specific barrier to passive transport through the nuclear pore complex."

This archive contains all the alignments and trees used in the HIPPI paper [1]. The pfam.tar archive contains the PFAM families used to build the HMMs and BLAST databases. The file structure is: ./X/Y/initial.fasttree ./X/Y/initial.fasta where X is a Pfam family, Y is the cross-fold set (0, 1, 2, or 3). Inside the folder are two files, initial.fasta which is the Pfam reference alignment with 1/4 of the seed alignment removed and initial.fasttree, the FastTree-2 ML tree estimated on the initial.fasta. The query.tar archive contains the query sequences for each cross-fold set. The associated query sequences for a cross-fold Y is labeled as query.Y.Z.fas, where Z is the fragment length (1, 0.5, or 0.25). The query files are found in the splits directory. [1] Nguyen, Nam-Phuong D, Mike Nute, Siavash Mirarab, and Tandy Warnow. (2016) HIPPI: Highly Accurate Protein Family Classification with Ensembles of HMMs. To appear in BMC Genomics.

The dataset includes bee community data from a study conducted down in southern Illinois across three forested public land sites. Bee diversity and abundance data, as well as environmental variables, are included for each plot. Each plot was visited a total of four times.

This study presents a cost-effective strategy for producing organic acids from glucose and xylose using the acid-tolerant yeast, Issatchenkia orientalis. I. orientalis was engineered to produce lactic acid from xylose, and the resulting strain, SD108XL, successfully converted sorghum hydrolysates into lactic acid. In order to enable low-pH fermentation, a self-buffering strategy, where the lactic acid generated by the SD108XL strain during fermentation served as a buffer, was developed. As a result, the SD108 strain produced 67 g/L of lactic acid from 73 g/L of glucose and 40 g/L of xylose, simulating a sugar composition of sorghum biomass hydrolysates. Moreover, techno-economic analysis underscored the efficiency of the self-buffering strategy in streamlining the downstream process, thereby reducing production costs. These results demonstrate the potential of I. orientalis as a platform strain for the cost-effective production of organic acids from cellulosic hydrolysates.

Census data collected at Trelease Woods in 1936 with information on tree species, stem count, diameter at breast height (DBH), and basal area. The plot boundaries from the 1936 census were georeferenced to subset 2018 census data for a direct comparison between the two census years.

These datasets provide the basis of our analysis in the paper - The Potential Impact of a Clean Energy Society On Air Quality. All datasets here are from the model output (CAM4-chem). All the simulations were run to steady-state and only the outputs used in the analysis are archived here.

This dataset contains all the raw data, figures, and Prism files corresponding to each experiment performed for the paper “Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.”

Drainage network analysis is fundamental to understanding the characteristics of surface hydrology. Based on elevation data, drainage network analysis is often used to extract key hydrological features like drainage networks and streamlines. Limited by raster-based data models, conventional drainage network algorithms typically allow water to flow in 4 or 8 directions (surrounding grids) from a raster grid. To resolve this limitation, this paper describes a new vector-based method for drainage network analysis that allows water to flow in any direction around each location. The method is enabled by rapid advances in Light Detection and Ranging (LiDAR) remote sensing and high-performance computing. The drainage network analysis is conducted using a high-density point cloud instead of Digital Elevation Models (DEMs) at coarse resolutions. Our computational experiments show that the vector-based method can better capture water flows without limiting the number of directions due to imprecise DEMs. Our case study applies the method to Rowan County watershed, North Carolina in the US. After comparing the drainage networks and streamlines detected with corresponding reference data from US Geological Survey generated from the Geonet software, we find that the new method performs well in capturing the characteristics of water flows on landscape surfaces in order to form an accurate drainage network. This dataset contains all the code, notebooks, datasets used in the study conducted for the research publication titled " A Vector-Based Method for Drainage Network Analysis Based on LiDAR Data ". ## What's Inside A quick explanation of the components * `A Vector Approach to Drainage Network Analysis Based on LiDAR Data.ipynb` is a notebook for finding the drainage network based on LiDAR data *`Picture1.png` is a picture representing the pseudocode of our new algorithm * HPC` folder contains codes for running the algorithm with sbatch in HPC ** `execute.sh` is a bash script file that use sbatch to conduct large scale analysis for the algorithm ** `run.sh` is a bash script file that calls the script file `execute.sh` for large scale calculation for the algorithm ** `run.py` includes the codes implemented for the algorithm * `Rowan Creek Data` includes data that are used in the study ** `3_1.las` and `3_2.las ` are the LiDAR data files that is used in our analysis presented in the paper. Users may use this data file to reproduce our results and may replace it with their own LiDAR file to run this method over different areas ** `reference` folder includes reference data from USGS *** `reference_3_1.tif` and `reference_3_2.tif` are reference data for the drainage system analysis retrieved from USGS.

This document contains the Supplemental Materials for Chapter 4: Climate Change Impacts on Agriculture from the report "An Assessment of the Impacts of Climate Change in Illinois" published in 2021.

This dataset helps to investigate the Spatial Accessibility to HIV Testing, Treatment, and Prevention Services in Illinois and Chicago, USA. The main components are: population data, healthcare data, GTFS feeds, and road network data. The core components are: 1) `GTFS` which contains GTFS (<a href="https://gtfs.org/">General Transit Feed Specification</a>) data which is provided by Chicago Transit Authority (CTA) from <a href="https://developers.google.com/transit/gtfs">Google's GTFS feeds</a>. Documentation defines the format and structure of the files that comprise a GTFS dataset: <a href="https://developers.google.com/transit/gtfs/reference?csw=1">https://developers.google.com/transit/gtfs/reference?csw=1</a>. 2) `HealthCare` contains shapefiles describing HIV healthcare providers in Chicago and Illinois respectively. The services come from <a href="https://locator.hiv.gov/">Locator.HIV.gov</a>. 3) `PopData` contains population data for Chicago and Illinois respectively. Data come from The American Community Survey and <a href="https://map.aidsvu.org/map">AIDSVu</a>. AIDSVu (https://map.aidsvu.org/map) provides data on PLWH in Chicago at the census tract level for the year 2017 and in the State of Illinois at the county level for the year 2016. The American Community Survey (ACS) provided the number of people aged 15 to 64 at the census tract level for the year 2017 and at the county level for the year 2016. The ACS provides annually updated information on demographic and socio economic characteristics of people and housing in the U.S. 4) `RoadNetwork` contains the road networks for Chicago and Illinois respectively from <a href="https://www.openstreetmap.org/copyright">OpenStreetMap</a> using the Python <a href="https://osmnx.readthedocs.io/en/stable/">osmnx</a> package. <b>The abstract for our paper is:</b> Accomplishing the goals outlined in “Ending the HIV (Human Immunodeficiency Virus) Epidemic: A Plan for America Initiative” will require properly estimating and increasing access to HIV testing, treatment, and prevention services. In this research, a computational spatial method for estimating access was applied to measure distance to services from all points of a city or state while considering the size of the population in need for services as well as both driving and public transportation. Specifically, this study employed the enhanced two-step floating catchment area (E2SFCA) method to measure spatial accessibility to HIV testing, treatment (i.e., Ryan White HIV/AIDS program), and prevention (i.e., Pre-Exposure Prophylaxis [PrEP]) services. The method considered the spatial location of MSM (Men Who have Sex with Men), PLWH (People Living with HIV), and the general adult population 15-64 depending on what HIV services the U.S. Centers for Disease Control (CDC) recommends for each group. The study delineated service- and population-specific accessibility maps, demonstrating the method’s utility by analyzing data corresponding to the city of Chicago and the state of Illinois. Findings indicated health disparities in the south and the northwest of Chicago and particular areas in Illinois, as well as unique health disparities for public transportation compared to driving. The methodology details and computer code are shared for use in research and public policy.

Bigheaded carp were collected from the Illinois and Des Plaines Rivers, parts of the Illinois Waterway, from May to November 2018. A total of 93 fish were collected during sampling for a study comprised of 40 females, 41 males, and 12 unsexed fish. GC/MS metabolite profiling analysis detected 180 compounds. Livers from carp at the leading edge had differences in energy use and metabolism, and suppression of protective mechanisms relative to downstream fish; differences were consistent across time. This body of work provides evidence that water quality is linked to carp movement in the Illinois River. As water quality in this region continues to improve, consideration of this impact on carp spread is essential to protect the Great Lakes.